Phase 2 trial of daily, oral polyphenon E in patients with asymptomatic, Rai stage 0 to II chronic lymphocytic leukemia. Regulatory T cell modulation by green tea in chronic lymphocytic leukemia. As opposed to acute lymphocytic leukemia, chronic lymphocytic leukemia is a slow progressing disease and is diagnosed later in a dog's life, usually at the age of 10 years. 2012;118:1827. This disease is more common in white males and the elderly, … Factors that may increase the risk of chronic lymphocytic leukemia include: Chronic lymphocytic leukemia may cause complications such as: Mayo Clinic does not endorse companies or products. Chronic Lymphocytic Leukemia is the most common form of adult Leukemia in the United States and the western world. There are also important differences in symptoms and treatment. It often occurs during or after middle age; it rarely occurs in children. Chronic lymphocytic leukemia (CLL) is a type of cancer that affects the blood and bone marrow. http://www.nccn.org/professionals/physician_gls/f_guidelines.asp. Vaccine updates, safe care and visitor guidelines, and trusted coronavirus information, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, See our safety precautions in response to COVID-19, Book: Mayo Clinic Family Health Book, 5th Edition, Newsletter: Mayo Clinic Health Letter — Digital Edition, Sharing Mayo Clinic: First awake robotics-guided biopsy offers precision in diagnosis, FREE book offer – Mayo Clinic Health Letter, New Year Special -  40% off – Mayo Clinic Diet Online. CLL is found almost exclusively in adults. Later non-painful lymph node swelling, feeling tired, fever, night sweats, or weight loss for no clear reason may occur. CLL is more common in older people (over 70). Accessed Aug. 9, 2017. Staging is a way of describing where the cancer is located, if or where it has spread, and whether it is affecting other parts of the body. We report 2 cases of biclonal CLL. but not completely. Leukemic transformation is initiated by specific genomic alterations that impair apoptosis of clonal B‐cells. Lymphocytes help your body fight infection. Philadelphia, Pa.: Churchill Livingstone Elsevier; 2014. https://www.clinicalkey.com. Hairy Cell Leukemia Treatment (PDQ®)–Health Professional Version. In Germany, the annual incidence in men is 7.4/100.000 and in women 4.8/100.000, and the median age of onset is between 70 and 75 years. At the American Cancer Society, we’re on a mission to free the world from cancer. The histopathologic features of most CLL/SLL are typical: a proliferation of small, mature B-cells with irregularly condensed chromatin, dim CD20 expression, CD5 co-expression, light chain restriction, and no evidence of t(11;14). Whether you want to learn about treatment options, get advice on coping with side effects, or have questions about health insurance, we’re here to help. Lymphocytes help your body fight infection. Knowing the exact type of leukemia helps doctors better predict each patient's outlook and select the best treatment. Pain in the upper left portion of the abdomen, which may be caused by an enlarged spleen. You can help reduce your risk of cancer by making healthy choices like eating right, staying active and not smoking. Available Every Minute of Every Day. Clin Lymphoma Myeloma Leuk. Approved by the Cancer.Net Editorial Board, 10/2017. Many people don't have any symptoms for at least a few years. CLL/SLL is defined as a monoclonal lymphoproliferative disease characterized by the proliferation and accumulation of morphologically mature but immunologically dysfunctional B-cell lymphocytes that … B lymphocytes (also known as B-cells) are specialised white blood cells. In leukemia, there is an overproduction of blast cells. Find out how CLL is tested for, diagnosed, and staged. DeVita, Hellman, and Rosenberg's Cancer: Principles and Practice of Oncology. What patients and caregivers need to know about cancer, coronavirus, and COVID-19. Advertising revenue supports our not-for-profit mission. Chronic lymphocytic leukaemia is a cancer that affects the blood and bone marrow. The cancer (leukemia) cells start in the bone marrow but then go into the blood. It's a type of cancer that starts in cells that become certain white blood cells (called lymphocytes) in the bone marrow. Accessed Aug. 9, 2017. But over time, the cells grow … CLL is a blood cancer that begins from lymphoid cells, which can become B cells, T cells, and natural killer cells.1,2 Chronic lymphocytic leukaemia (CLL) is the most common leukaemia among the adults in the Western World. Leukemia is myeloid or lymphocytic depending on which bone marrow cells the cancer starts in. 2018 Mar 14. pii: blood-2017-09-806398. They're made in … Leukemia is cancer that starts in the blood-forming cells of the bone marrow. Animated Mnemonics (Picmonic): https://www.picmonic.com/viphookup/medicosis/ - With Picmonic, get your life back by studying less and remembering more. Both B-PLL and T-PLL tend to grow and spread faster than the usual type of CLL. Cancer Management: A Multidisciplinary Approach. The American Cancer Society is a qualified 501(c)(3) tax-exempt organization. Become a volunteer, make a tax-deductible donation, or participate in a fundraising event to help us save lives. American Cancer Society medical information is copyrighted material. The American Cancer Society medical and editorial content team. National Comprehensive Cancer Network, Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Version 5.2018 -- March 26, 2018. In chronic leukemia, the cells can mature partly (and more are like normal white blood cells). The 2016 revision of the World Health Organization classification of … It often occurs during or after middle age and is rare in children. Chronic lymphocytic leukaemia is a type of cancer that affects the white blood cells and tends to progress slowly over many years. Large granular lymphocyte (LGL) leukemia: This is another rare form of chronic leukemia. The major complications of CLL will be discussed here. Chronic lymphocytic leukemia is one of the four types of leukemia. Dedicated to addressing the unmet needs of the (CLL) chronic lymphocytic leukemia and related blood cancer communities, we explain the rapidly changing therapeutic landscape and the … Get The Best Care for Your Chronic Lymphocytic Leukemia (CLL) The CLL Society Inc. is a patient–centric, physician–curated nonprofit organization focused on patient education, support and research. 2013;119:363. Chronic lymphocytic leukemia (CLL) is a cancer that starts in blood stem cells. Philadelphia, Pa: Elsevier; 2014:1958–1978. Although doctors can very rarely cure CLL, survival rates for this cancer are typically good. Lymphocytes are an important part of the immune system, and they protect the body against all infections. Chronic lymphocytic leukemia is the most frequent adult leukemia. Chronic lymphocytic leukemia (CLL) symptoms usually develop over time. Chronic lymphocytic leukemia (CLL) is a type of cancer that affects the blood and bone marrow. Beyond being ineffective, these abnormal lymphocytes continue to live and multiply, when normal lymphocytes would die. Chronic lymphocytic leukemia is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell). 2017;26:3419. Chronic lymphocytic leukemia (CLL) is the most common chronic leukemia in adults. This is a lethal condition in dogs. Learn more about chronic lymphocytic leukemia research: B-Cell Lymphoproliferative Disorders Laboratory; University of Iowa/Mayo Clinic Lymphoma SPORE; Hematological Malignancies Program; Hematology Research; Blood cell and bone marrow cancer research is conducted in coordination with the Mayo Clinic Cancer Center. Chronic lymphocytic leukemia develops when the process of blood cell production fails, leading to the creation of more and more immature white blood cells at the expense of healthy cells.Since lymphocytes are responsible for fighting infection, the absence of creation of lymphocytes deprives the body to do so. Help make it a reality. Make a donation. As the stem cells of the blood develop, they become blast cells (blasts), which are immature blood cells. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. Without treatment, most people with acute leukemia would only live a few months. The common form of CLL starts in B lymphocytes. Most people with it will respond to some form of treatment, but over time they tend to relapse (the cancer comes back). The abnormal lymphocytes accumulate in the blood and certain organs, where they cause complications. It often occurs during or after middle age; it rarely occurs in children. Chronic lymphocytic leukemia most commonly affects older adults. These cells may look fairly normal, but they're not. Accessed at www.nccn.org/professionals/physician_gls/pdf/cll.pdf on April 12, 2018. Wierda WG, O'Brien S. Chronic lymphocytic leukemias. The disease has not, however, received its fair share of research dollars. This mutation causes the blood cells to produce abnormal, ineffective lymphocytes. But over time, the cells grow and spread to other parts of the body, including the lymph nodes, liver, and spleen. Chronic lymphocytic leukemia. Prolymphocytic leukemia (PLL): In this type of leukemia the cancer cells are a lot like normal cells called prolymphocytes. Chronic Lymphocytic Leukemia - A Reference Guide (BONUS DOWNLOADS) (The Hill Resource and Reference Guide Book 112) by Joseph Estenson. So it may take a long time before the patient needs treatment. Fort Washington, Pa.: National Comprehensive Cancer Network. Other types of acute leukemia have a less … Chronic Lymphocytic Leukemia Research Consortium. 5th ed. Chronic lymphocytic leukemia (CLL) is a type of leukemia where the bone marrow produces abnormal lymphocytes which are not able to function properly. 11th ed. 9th ed. Enlargement of the spleen and low red blood cells (anemia) may also occur. They generally don't fight infection as well as normal white blood cells do. Children are almost never affected. Chronic lymphocytic leukemia (also called CLL) is a blood and bone marrow disease that usually gets worse slowly. CLL and SLL are essentially the same disease, with the only difference being the location where the cancer primarily occurs. Natural Medicines. Chronic Lymphocytic Leukemia Treatment (PDQ®)–Health Professional Version. Chronic lymphocytic leukemia (CLL) Is a type of blood cancer that begins in the bone marrow; Can progress either slowly or quickly depending on the form it takes; Click here to access CLL statistics. This increases the number of white blood cells in the blood. In chronic lymphocytic leukemia (CLL), there are too many lymphocytes, a type of white blood cell. Green tea. Accessed at www.cancer.gov/types/leukemia/hp/cll-treatment-pdq on April 12, 2018. Under normal conditions they produce immunoglobulins (also called antibodies) that help protect our bodies against infection and disease. What You Should Know. Dr William Wierda from MD Anderson reviews key studies on chronic lymphocytic leukemia therapies from ASH 2020, including the phase 3 UNITY trial, next-generation BTK inhibitors, and CAR-T therapy. Early on there are typically no symptoms. Chronic lymphocytic leukemia (CLL) is a cancer that affects a type of white blood cell called a "lymphocyte." We couldn’t do what we do without our volunteers and donors. It often occurs during or after middle age; it rarely occurs in children. Byrd JC, Flynn JM. Cancer. New York, N.Y.: McGraw-Hill Education; 2016. http://www.accessmedicine.mhmedical.com. Treatment for chronic lymphocytic leukaemia (CLL) largely depends how far developed it is when it's diagnosed. We can even find you a free ride to treatment or a free place to stay when treatment is far from home. National Cancer Institute. Cancers that start elsewhere and then spread to the bone marrow are not leukemia. CLL is the most common type of leukemia in adults. Chronic lymphocytic leukemia features an accumulation of lymphocytes in the blood that are incompetent and not completely functional. 5th ed. They may crowd healthy cells out of the bone marrow and interfere with normal blood cell production. If you’ve got CLL, your body produces too many lymphocytes which don’t work properly. Over time, CLL may also spread to the lymph nodes … Click here to access CLL statistics. Can progress either slowly or quickly depending on the form it takes. Hematologist/oncologist disease-specific expertise and survival: Lessons from chronic lymphocytic leukemia (CLL)/small lymphocytic leukemia (SLL). Accessed Aug. 9, 2017. Leukemia is different from other types of cancer that start in organs like the lungs, colon, or breast and then spread to the bone marrow. In leukemia, there is an overproduction of blast cells. Early on there are typically no symptoms. Chronic lymphocytic leukemia (CLL) affects everyone differently. Treatment is based on the severity of associated symptoms as well as the rate of cancer growth. Diagnosis . Children are almost never affected. Cancer Information, Answers, and Hope. Tax ID Number: 13-1788491. CLL is the most common leukaemia in adults. It mostly affects people over the age of 60 and is rare in people under 40. The bone marrow makes damaged lymphocytes and the body has trouble fighting infections. Demonstration of a monotypic CD19+, CD5+ B-cell population is central to the diagnosis. Being an employee of MD Anderson Cancer Center since 2001, affords her the opportunity to work with world-renowned CLL experts. © 2021 American Cancer Society, Inc. All rights reserved. CLL usually occurs in adults around the age of 70 and begins in the bone marrow and then spreads to the blood. Warner KJ. The clinical and biological picture of CLL is very heterogeneous. Chronic lymphocytic leukemia (CLL) is well characterized clinically and immunophenotypically. It’s also important to follow recommended screening guidelines, which can help detect certain cancers early. Free with Kindle Unlimited membership Learn More Or $2.99 to buy. This content does not have an Arabic version. It's a chronic condition so it tends to develop slowly over many years. Chronic lymphocytic leukemia (CLL) is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell). Until then, try to: 1. What's known is that something happens to cause a genetic mutation in the DNA of blood-producing cells. The disease typically occurs in elderly patients and has a highly variable clinical course. Chronic lymphocytic leukemia is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell). It often occurs during or after middle age; it rarely occurs in children. Hematologists and oncologists are specialists who treat people who have CLL or other types of blood cancer. Drugs used to treat Chronic Lymphocytic Leukemia The following list of medications are in some way related to, or used in the treatment of this condition. It is the most common type of leukemia in adults living in Western countries, and even though the majority of patients survive, some of them may die due to complications we will explain further. Chronic lymphocytic leukemia (CLL) is the most common leukemic disease in elderly patients. CLL is the result of various genetic mutations in the DNA of cells that produce blood. Chronic lymphocytic leukemia (CLL) is the commonest leukemia in western countries. Those who do develop signs and symptoms may experience: Make an appointment with your doctor if you have any persistent signs and symptoms that worry you. Ding W, et al. The malignant cells are found in blood and bone marrow, and collect in and enlarge the lymph nodes. In: Pazdur R, Wagman LD, Camphausen KA, Hoskins WJ, eds. Accessed Aug. 9, 2017. Later non-painful lymph node swelling, feeling tired, fever, night sweats, or weight loss for no clear reason may occur. CLL is one of the most common types of leukemia in adults. Chronic lymphocytic leukemia. Lymphocytic leukemias (also known as lymphoid or lymphoblastic leukemia) start in the cells that become lymphocytes. That’s why all CLL patients should follow unique treatment plans tailored to their specific needs. The disease is twice as common in men as women. The disease typically occurs in elderly patients and has a highly variable clinical course. Chronic lymphocytic leukemia is typically a slow-growing cancer that may not require treatment. CLL usually occurs in adults around the age of 70 and begins in the bone marrow and then spreads to the blood. Chronic lymphocytic leukemia. What You Should Know. Thus, other “normal” causes of death have as much of a chance of killing you as CLL. Shanafelt TD, et al. What is CLL? What patients and caregivers need to know about cancer, coronavirus, and COVID-19. Chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) is an indolent malignancy characterized by increased production of mature but dysfunctional B lymphocytes. Blood. In people with CLL, lymphocytes undergo a malignant (cancerous) change and … CRC sites. Until we do, we’ll be funding and conducting research, sharing expert information, supporting patients, and spreading the word about prevention. Chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) are cancers that affect lymphocytes. Stem cells are basic cells that develop into different types of cells that have different jobs. This type of leukemia gets its name from the way the cells look under the microscope -- they have fine projections on their surface that make them look "hairy." Lymphomas are also cancers that start in those cells. Doctors and researchers are working to understand the exact mechanism that causes chronic lymphocytic leukemia. That’s where specialists come in: a CLL specialist, called a hematologist-oncologist, has the right skills and insight … The leukemia cells survive longer than normal cells, and build up, crowding out normal cells in the bone marrow. Together, we’re making a difference – and you can, too. Chronic lymphocytic leukemia: The most common form of leukemia in adults, in which lymphocytes look fairly normal but are not fully mature and do not function correctly against infection. Early in the course of the disease, CLL often has little effect on a person’s well-being. The cancer cells are a type of B lymphocyte but they're different from those seen in CLL. Chemotherapy is the main treatment if it's more advanced. What's New in Chronic Lymphocytic Leukemia Research and Treatment? Chronic lymphocytic leukemia. The main difference between lymphocytic leukemias and lymphomas is that in leukemia, the cancer cells are mainly in the bone marrow and blood, while in lymphoma they tend to be in lymph nodes Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults. Fort Washington, Pa.: National Comprehensive Cancer Network. Cells in nearly any part of the body can become cancer and can spread to other parts of the body. CLL (and the corresponding nodal entity small lymphocytic lymphoma, SLL) is classified as a lymphoproliferative disorder characterised by the relentless accumulation of mature B-lymphocytes showing a peculiar immunophenotype in the peripheral blood, bone marrow, lymph nodes and spleen. Chronic lymphocytic leukemia (CLL) is a cancer of the blood in which too many lymphocytes, a type of white blood cell, are produced by the bone marrow and by organs of the lymph system. ON THIS PAGE: You will learn about how doctors describe the growth or spread of CLL. Cancer.org is provided courtesy of the Leo and Gloria Rosen family. Chronic lymphocytic leukemia is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell). Our team of expert journalists brings you all angles of the cancer story – from breaking news and survivor stories to in-depth insights into cutting-edge research. Diagnosis . Normally, the bone marrow produces hematopoietic stem cells that may become a red blood cell, white blood cell or platelets. We’ve invested more than $4.9 billion in cancer research since 1946, all to find more – and better – treatments, uncover factors that may cause cancer, and improve cancer patients’ quality of life. Boddy CS, Ma S. Frontline Therapy of CLL: Evolving Treatment Paradigm. Cancer starts when cells start to grow out of control. What does it take to outsmart cancer? Eighty per cent of the patients are asymptomatic at diagnosis and 30% of the patients will be never treated. Patients. Drugs that suppress the immune system may help, but the aggressive types are very hard to treat. Wierda WG, Lamanna N, Weiss MA. Chronic lymphocytic leukemia (also called CLL) is a cancer of the blood and bone marrow that usually gets worse slowly. The cancer cells are large and have features of either T lymphocytes or another type of lymphocyte called natural killer (NK) cells. Research. Close Critical Alert Banner. Hallek M, Cheson BD, Catovsky D, et al. Pembrolizumab in patients with CLL and Richter transformation or with relapsed CLL. But your primary care doctor will not have all the information you need to manage your CLL successfully. This content does not have an English version. Patients with CLL commonly develop complications associated with the intrinsic immune dysfunction that results in immunodeficiency and the development of autoimmune disorders. Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma: Treatment Options. This is a lethal condition in dogs. The mission of the CLL Foundation is to raise money for research that will lead to a better understanding of the disease and to better treatments for those who have been diagnosed with the disease. Lawrence, KS: CMPMedica; 2008:843-858. Découvrez et achetez Chronic Lymphocytic Leukemia. Usually CLL does not cause any symptoms. Use the menu to see other pages. This allows them to build up in the bone marrow, crowding out normal cells. Routine cases of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) often present little diagnostic challenge. © 1998-2021 Mayo Foundation for Medical Education and Research (MFMER). Over time, they can “crowd out” other healthy blood cells in your bone marrow, such as your red blood cells and platelets. CLL may also be referred to as chronic lymphoid leukemia. Swerdlow SH, Campo E, Pileri SA, et al. These DNA changes occur over the course of a life span, rather than like other genetic changes that are passed down before birth. In the last few years, several biologic markers such as cytogenetics, IgVH mutations, CD38 and ZAP-70 expression in leukemic cells have shown to offer important prognostic information. Advances in Chronic Lymphocytic Leukemia (Advances in Experimental Medicine and Biology Book 792) Book 792 of 581: Advances in Experimental Medicine … Livraison en Europe à 1 centime seulement ! Learn more about these partnerships and how you too can join us in our mission to save lives, celebrate lives, and lead the fight for a world without cancer. Chronic lymphocytic leukemia treatment (PDQ). But there are some rare types of leukemia that share some features with CLL. National Cancer Institute. In: Abeloff's Clinical Oncology. Chronic lymphocytic leukemia (CLL) is a type of blood cancer that begins in the bone marrow and enters into the blood. In: Niederhuber JE,Armitage JO, Doroshow JH, Kastan MB, Tepper JE, eds. Chronic lymphocytic leukemia care at Mayo Clinic. It can take a long time before chronic leukemias cause problems, and most people can live with them for many years. Kindle Edition $0.00 $ 0. The disease typically occurs in elderly patients and has a highly variable clinical course. Find out about chronic lymphocytic leukaemia (CLL), where it starts and about the different types of leukaemia. Imagine a world free from cancer. CLL is one of the most common types of leukemia in adults. Most LGL leukemias are slow-growing, but a small number are more aggressive (they grow and spread quickly). Chronic lymphocytic leukemia (CLL) is a cancer that affects a type of white blood cell called a lymphocyte. CLL and SLL are essentially the same disease, with the only difference being the location where the cancer primarily occurs. Shanafelt TD, et al. As the stem cells of the blood develop, they become blast cells (blasts), which are immature blood cells. Chronic lymphocytic leukemia features an accumulation of lymphocytes in the blood that are incompetent and not completely functional. To learn more about how cancers start and spread, see What Is Cancer? From basic information about cancer and its causes to in-depth information on specific cancer types – including risk factors, early detection, diagnosis, and treatment options – you’ll find it here. Leukemic transformation is initiated by specific genomic alterations that impair apoptosis of clonal B‐cells. Some kinds of CLL will be stable for years and won’t need treatment. Mayo Clinic, Rochester, Minn. June 15, 2017. At some point, leukemia cells leave the bone marrow and spill into the bloodstream. AskMayoExpert. The American Cancer Society couldn’t do what we do without the support of our partners. Accessed Aug. 9, 2017. Chronic lymphocytic leukaemia (CLL) at a glance. These abnormal lymphocytes don’t function as white blood cells should to help your immune system. International Journal of Immunopathology and Pharmacology. Guidelines for diagnosis, indications for treatment, response assessment and supportive management of chronic lymphocytic leukemia. Accessed at www.cancer.gov/types/leukemia/hp/hairy-cell-treatment-pdq on April 12, 2018. The average age at diagnosis is 72. Her professional experience as it relates to chronic lymphocytic leukemia is extensive. Blood. Mayo Clinic, Rochester, Minn. Sept. 3, 2017. But chronic leukemias tend to be harder to cure than acute leukemias. For more information about this type of leukemia, read the article below. Chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) are cancers that affect lymphocytes. These are immature forms of B lymphocytes (B-PLL) or T lymphocytes (T-PLL). Chronic lymphocytic leukemia is considered the most common type of leukemia in the Western hemisphere; its prevalence in Europe and North America ranges from 29-38% of all leukaemias 1.It primarily affects adults ~65-70 years of age 3.. Clinical presentation This disease is more common in white males and the elderly, … The term "chronic" in chronic lymphocytic leukemia comes from the fact that it typically progresses more slowly than other types of leukemia. 2018;18(4):249-256. CLL is the most common type of leukemia in adults in Western countries. Many people don't have any symptoms for at least a few years. Leukemia cells also don't die when they should. Chronic lymphocytic leukemia is a condition in which, due to mutations in the bone marrow, the amount of white cells produced is in excess, while other important blood cells are in deficit. Early signs and symptoms may include swollen lymph nodes, fatigue, weight loss, fever, night sweats and/or frequent infections. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. See our safety precautions in response to COVID-19. Cancer-related fatigue. If the CLL cells have low amounts of these proteins, the leukemia tends to grow more slowly and have better long-term outcomes. CLL is one of the most common types of leukemia in adults. Chronic lymphocytic leukemia (CLL) is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell). CLL is the second most common type of leukemia in adults. Routine cases of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) often present little diagnostic challenge. 00. and other tissues. Chronic lymphocytic leukemia (CLL) is a type of cancer of the white blood cells (lymphocytes). Mayo Clinic is a not-for-profit organization. Chronic lymphocytic leukemia (CLL) is the commonest leukemia in western countries. 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